MOTS-C
Metabolic
MOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA gene of the mitochondrial genome. It is a 16-amino acid peptide that acts as a retrograde signal from mitochondria to the nuclear genome. MOTS-c is studied as an exercise mimetic that activates AMPK and regulates the folate-methionine cycle in metabolic research models.
$40.00
In StockFor research purposes only. Not for human consumption.
Mechanism of Action
MOTS-c is a mitochondrial-derived peptide that translocates to the nucleus under metabolic stress, activating AMPK and regulating the folate-methionine cycle. It enhances glucose uptake in skeletal muscle independent of insulin and acts as a retrograde signal from mitochondria to the nuclear genome. Circulating levels increase with exercise and decline with age.
Research Focus Areas
- Metabolic homeostasis and insulin sensitivity
- Exercise mimetic pathways (AMPK)
- Mitochondrial communication signaling
- Age-related metabolic decline models