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Melanotan-1
Qty: 10mg / 1 BOTTLE
Purity: >99%
Mol: —
2-8°C
Performance

Melanotan-1

Performance

Melanotan-1 (afamelanotide) is a synthetic linear analog of alpha-melanocyte-stimulating hormone (¦Á-MSH) with the sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH?. It was developed as a more stable, longer-acting analog of native ¦Á-MSH by substituting norleucine at position 4 and D-phenylalanine at position 7, increasing receptor binding affinity at the melanocortin-1 receptor (MC1R) and extending its half-life in research models. Melanotan-1 has been extensively studied for its role in melanocyte stimulation, eumelanin synthesis, photoprotective mechanisms, and melanogenesis signaling pathways.

$45.00

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For research purposes only. Not for human consumption.

Mechanism of Action

Melanotan-1 binds selectively to the melanocortin-1 receptor (MC1R) expressed on melanocytes, activating Gαs-coupled adenylate cyclase and elevating intracellular cAMP. Elevated cAMP activates PKA, which phosphorylates CREB and upregulates MITF (microphthalmia-associated transcription factor) expression. MITF drives transcription of melanogenesis enzymes including tyrosinase (TYR), TYRP1, and TYRP2, leading to eumelanin production in pigment cells. The D-Phe substitution confers resistance to enzymatic degradation, providing extended MC1R activation compared to native α-MSH in research models.

Key Benefits

Stimulates melanocyte activity research
Supports natural tanning pathway studies
MC1R receptor agonist research
Eumelanin synthesis pathway models
Photoprotective mechanism studies
MITF transcription pathway research