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Kisspeptin
Qty: 10mg / 1 BOTTLE
Purity: >99%
Mol: —
2-8°C
Performance

Kisspeptin

Performance

Kisspeptin (Kisspeptin-10) is an endogenous neuropeptide encoded by the KISS1 gene, representing the C-terminal 10-amino acid active fragment of the full-length Kisspeptin-54 precursor. It is the primary endogenous ligand for the GPR54 (KISS1R) receptor and plays a critical role in hypothalamic-pituitary-gonadal (HPG) axis regulation. Kisspeptin has been extensively studied for its role in GnRH neuron activation, gonadotropin (LH/FSH) release support, and neuroendocrine reproductive axis research models.

$55.00

In Stock

size

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For research purposes only. Not for human consumption.

Mechanism of Action

Kisspeptin binds to the GPR54 (KISS1R) G-protein coupled receptor on GnRH neurons in the hypothalamus, activating Gαq/11-mediated phospholipase C signaling. This results in IP3/DAG-mediated calcium mobilization and membrane depolarization, driving pulsatile GnRH release into the portal circulation. GnRH then stimulates pituitary gonadotroph cells to secrete LH and FSH, completing the hypothalamic-pituitary-gonadal axis signaling cascade in research models.

Key Benefits

Hypothalamic reproductive axis support
Gonadotropin release support research
GPR54 receptor activation studies
GnRH neuron signaling models
LH/FSH pathway research
Neuroendocrine regulation studies