Glutathione
Antioxidant
Glutathione (¦Ã-glutamylcysteinylglycine) is the most abundant intracellular antioxidant in mammalian cells. This tripeptide serves as the master antioxidant, directly neutralizing reactive oxygen species (ROS) and serving as a cofactor for glutathione peroxidase. It plays essential roles in Phase II detoxification, immune cell function, and maintenance of protein thiol redox states.
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Mechanism of Action
Glutathione serves as the primary intracellular antioxidant, directly neutralizing reactive oxygen species (ROS) and serving as a cofactor for glutathione peroxidase and glutathione S-transferase. It conjugates with xenobiotics for Phase II detoxification and maintains the redox state of protein thiols critical for enzyme function and cellular signaling.
Research Focus Areas
- Oxidative stress and free radical neutralization
- Phase II detoxification pathways
- Immune cell function and proliferation
- Hepatoprotection and liver function