5-Amino-1MQ
Metabolic
5-Amino-1-methylquinolinium (5-Amino-1MQ) is a selective, cell-permeable small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme responsible for methylating nicotinamide using SAM as a methyl donor. By blocking NNMT activity, 5-Amino-1MQ has been studied for its role in increasing NAD+ and SAM bioavailability, supporting metabolic regulation, mitochondrial biogenesis, and hypothalamic neurotransmitter pathway function in research models. It has attracted significant research interest for its potential role in metabolic homeostasis and cellular energy regulation.
$55.00
In StockFor research purposes only. Not for human consumption.
Mechanism of Action
5-Amino-1MQ competitively inhibits NNMT by occupying the nicotinamide binding site, preventing the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide. This inhibition increases intracellular NAD+ precursor availability and restores SAM pools, supporting methylation capacity throughout the cell. Elevated NAD+ levels activate SIRT1 and AMPK pathways, promoting mitochondrial biogenesis and fat oxidation in adipocyte and hypothalamic research models. The compound has also been studied for its effects on polyamine biosynthesis and mTOR signaling pathway modulation.
Research Focus Areas
- NNMT inhibition and NAD+ pathway research
- Metabolic regulation and mitochondrial biogenesis studies
- Hypothalamic neurotransmitter support research models
- SIRT1/AMPK pathway activation studies